In Vitro and In Vivo Activities of the Novel Ketolide RBx 14255 against Clostridium difficile

The MIC(90) of RBx 14255, a novel ketolide, against Clostridium difficile was 4 μg/ml (MIC range, 0.125 to 8 μg/ml), and this drug was found to be more potent than comparator drugs. An in vitro time-kill kinetics study of RBx 14255 showed time-dependent bacterial killing for C. difficile. Furthermor...

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Hauptverfasser: Kumar, Manoj, Mathur, Tarun, Barman, Tarani K., Ramkumar, G., Bhati, Ashish, Shukla, Gunjan, Kalia, Vandana, Pandya, Manisha, Raj, V. Samuel, Upadhyay, Dilip J., Vaishnavi, Chetana, Chakrabarti, Anjan, Das, Biswajit, Bhatnagar, Pradip K.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2012
Schlagworte:
Experimental Therapeutics
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3486553/
https://ncbi.nlm.nih.gov/pubmed/22869573
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00015-12
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