Antibiotic Resistance and Substrate Profiles of the Class A Carbapenemase KPC-6

The class A carbapenemase KPC-6 produces resistance to a broad range of β-lactam antibiotics. This enzyme hydrolyzes penicillins, the monobactam aztreonam, and carbapenems with similar catalytic efficiencies, ranging from 10(5) to 10(6) M(−1) s(−1). The catalytic efficiencies of KPC-6 against cephem...

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Bibliographic Details
Main Authors: Lamoureaux, Toni L., Frase, Hilary, Antunes, Nuno T., Vakulenko, Sergei B.
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2012
Subjects:
Mechanisms of Resistance
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3486543/
https://ncbi.nlm.nih.gov/pubmed/22908150
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01338-12
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