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Feasibility of a Fixed-Dose Regimen of Pyrazinamide and Its Impact on Systemic Drug Exposure and Liver Safety in Patients with Tuberculosis

Historically, dosing regimens for the treatment of tuberculosis (TB) have been proposed in an empirical manner. Dose selection has often been the result of efficacy trials in which drugs were administered regardless of the magnitude of the effect of demographic factors on drug disposition. This has...

詳細記述

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書誌詳細
主要な著者: Sahota, Tarjinder, Della Pasqua, Oscar
フォーマット: Artigo
言語:Inglês
出版事項: American Society for Microbiology 2012
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC3486525/
https://ncbi.nlm.nih.gov/pubmed/22777045
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.05988-11
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