Sequences in Glycoprotein gp41, the CD4 Binding Site, and the V2 Domain Regulate Sensitivity and Resistance of HIV-1 to Broadly Neutralizing Antibodies

The swarm of quasispecies that evolves in each HIV-1-infected individual represents a source of closely related Env protein variants that can be used to explore various aspects of HIV-1 biology. In this study, we made use of these variants to identify mutations that confer sensitivity and resistance...

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Autors principals: O'Rourke, Sara M., Schweighardt, Becky, Phung, Pham, Mesa, Kathryn A., Vollrath, Aaron L., Tatsuno, Gwen P., To, Briana, Sinangil, Faruk, Limoli, Kay, Wrin, Terri, Berman, Phillip W.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology 2012
Matèries:
Pathogenesis and Immunity
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3486483/
https://ncbi.nlm.nih.gov/pubmed/22933284
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01352-12
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