Gene Sequencing for Routine Verification of Pyrazinamide Resistance in Mycobacterium tuberculosis: a Role for pncA but Not rpsA

Pyrazinamide (PZA) is an important component of first-line therapy for the treatment of tuberculosis. Here, we evaluate targeted gene sequencing as a supplement to phenotypic PZA susceptibility testing of Mycobacterium tuberculosis. Routine sequencing of pncA, but not rpsA, is effective for verifica...

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Main Authors: Alexander, David C., Ma, Jennifer H., Guthrie, Jennifer L., Blair, Joanne, Chedore, Pam, Jamieson, Frances B.
Format: Artigo
Jezik:Inglês
Izdano: American Society for Microbiology 2012
Teme:
Mycobacteriology and Aerobic Actinomycetes
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3486241/
https://ncbi.nlm.nih.gov/pubmed/22895038
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JCM.00620-12
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