The selective sphingosine 1-phosphate receptor modulator BAF312 redirects lymphocyte distribution and has species-specific effects on heart rate

BACKGROUND AND PURPOSE: BAF312 is a next-generation sphingosine 1-phosphate (S1P) receptor modulator, selective for S1P(1) and S1P(5) receptors. S1P(1) receptors are essential for lymphocyte egress from lymph nodes and a drug target in immune-mediated diseases. Here, we have characterized the immuno...

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Main Authors: Gergely, P, Nuesslein-Hildesheim, B, Guerini, D, Brinkmann, V, Traebert, M, Bruns, C, Pan, S, Gray, NS, Hinterding, K, Cooke, NG, Groenewegen, A, Vitaliti, A, Sing, T, Luttringer, O, Yang, J, Gardin, A, Wang, N, Crumb, WJ, Saltzman, M, Rosenberg, M, Wallström, E
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Publishing Ltd 2012
Assuntos:
Research Papers
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3485666/
https://ncbi.nlm.nih.gov/pubmed/22646698
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1476-5381.2012.02061.x
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