Vav1 GEF activity is required for T cell mediated allograft rejection

The GDP exchange factor (GEF) Vav1 is a central signal transducer downstream of the T cell receptor and has been identified as a key factor for T cell activation in the context of allograft rejection. Vav1 has been shown to transduce signals both dependent and independent of its GEF function. The mo...

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Bibliographische Detailangaben
Hauptverfasser: Haubert, Dirk, Li, Jianping, Saveliev, Alexander, Calzascia, Thomas, Sutter, Esther, Metzler, Barbara, Kaiser, Daniel, Tybulewicz, Victor L.J., Weckbecker, Gisbert
Format: Artigo
Sprache:Inglês
Veröffentlicht: Elsevier 2012
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3485565/
https://ncbi.nlm.nih.gov/pubmed/22456277
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.trim.2012.03.003
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