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Vav1 GEF activity is required for T cell mediated allograft rejection
The GDP exchange factor (GEF) Vav1 is a central signal transducer downstream of the T cell receptor and has been identified as a key factor for T cell activation in the context of allograft rejection. Vav1 has been shown to transduce signals both dependent and independent of its GEF function. The mo...
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| Hauptverfasser: | , , , , , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Elsevier
2012
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3485565/ https://ncbi.nlm.nih.gov/pubmed/22456277 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.trim.2012.03.003 |
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