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Structure-Based Engineering Increased the Catalytic Turnover Rate of a Novel Phenazine Prenyltransferase

Prenyltransferases (PTs) catalyze the regioselective transfer of prenyl moieties onto aromatic substrates in biosynthetic pathways of microbial secondary metabolites. Therefore, these enzymes contribute to the chemical diversity of natural products. Prenylation is frequently essential for the pharma...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Zocher, Georg, Saleh, Orwah, Heim, Joel B., Herbst, Dominik A., Heide, Lutz, Stehle, Thilo
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2012
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3485228/
https://ncbi.nlm.nih.gov/pubmed/23119011
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0048427
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