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There is a correlation between the DNA affinity and mutagenicity of several 3-amino-1-methyl-5H-pyrido[4,3-b]indoles.

3-Amino-1-methyl-5H-pyrido[4,3-b]indole, previously reported to be a component of tryptophan pyrolysates, is an intensely mutagenic compound requiring microsomal activation for expression of mutagenicity. We have found that this species and several synthetic analogs interact noncovalently with calf...

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Bibliografische gegevens
Hoofdauteurs: Pezzuto, J M, Lau, P P, Luh, Y, Moore, P D, Wogan, G N, Hecht, S M
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 1980
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC348508/
https://ncbi.nlm.nih.gov/pubmed/6990411
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