There is a correlation between the DNA affinity and mutagenicity of several 3-amino-1-methyl-5H-pyrido[4,3-b]indoles.

3-Amino-1-methyl-5H-pyrido[4,3-b]indole, previously reported to be a component of tryptophan pyrolysates, is an intensely mutagenic compound requiring microsomal activation for expression of mutagenicity. We have found that this species and several synthetic analogs interact noncovalently with calf...

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Detalhes bibliográficos
Main Authors: Pezzuto, J M, Lau, P P, Luh, Y, Moore, P D, Wogan, G N, Hecht, S M
Formato: Artigo
Idioma:Inglês
Publicado em: 1980
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC348508/
https://ncbi.nlm.nih.gov/pubmed/6990411
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