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Dose-finding design for multi-drug combinations
BACKGROUND: Most of the current designs used for Phase I dose finding trials in oncology will either involve only a single cytotoxic agent or will impose some implicit ordering among the doses. The goal of the studies is to estimate the maximum tolerated dose (MTD), the highest dose that can be admi...
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| Main Authors: | , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2011
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3485079/ https://ncbi.nlm.nih.gov/pubmed/21652689 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1177/1740774511408748 |
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