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Mepacrine blocks beta-adrenergic agonist-induced desensitization in astrocytoma cells.

C6 astrocytoma cells contain beta-adrenergic receptors coupled to adenylate cyclase. A 2-hr exposure to l-isoproterenol results in an 80% decrease in cyclic AMP production in response to a subsequent challenge by l-isoproterenol (desensitization). This loss in responsiveness is paralleled by a 20-30...

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Udgivet i:Proc Natl Acad Sci U S A
Principais autores: Mallorga, P, Tallman, J F, Henneberry, R C, Hirata, F, Strittmatter, W T, Axelrod, J
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 1980
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC348490/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/6246490/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.77.3.1341
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