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Mepacrine blocks beta-adrenergic agonist-induced desensitization in astrocytoma cells.
C6 astrocytoma cells contain beta-adrenergic receptors coupled to adenylate cyclase. A 2-hr exposure to l-isoproterenol results in an 80% decrease in cyclic AMP production in response to a subsequent challenge by l-isoproterenol (desensitization). This loss in responsiveness is paralleled by a 20-30...
Enregistré dans:
| Publié dans: | Proc Natl Acad Sci U S A |
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| Auteurs principaux: | , , , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
National Academy of Sciences
1980
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC348490/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/6246490/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.77.3.1341 |
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