Mepacrine blocks beta-adrenergic agonist-induced desensitization in astrocytoma cells.

C6 astrocytoma cells contain beta-adrenergic receptors coupled to adenylate cyclase. A 2-hr exposure to l-isoproterenol results in an 80% decrease in cyclic AMP production in response to a subsequent challenge by l-isoproterenol (desensitization). This loss in responsiveness is paralleled by a 20-30...

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Publicat a:	Proc Natl Acad Sci U S A
Autors principals:	Mallorga, P, Tallman, J F, Henneberry, R C, Hirata, F, Strittmatter, W T, Axelrod, J
Format:	Artigo
Idioma:	Inglês
Publicat:	National Academy of Sciences 1980
Matèries:	Research Article
Accés en línia:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC348490/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/6246490/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.77.3.1341
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