Mepacrine blocks beta-adrenergic agonist-induced desensitization in astrocytoma cells.

C6 astrocytoma cells contain beta-adrenergic receptors coupled to adenylate cyclase. A 2-hr exposure to l-isoproterenol results in an 80% decrease in cyclic AMP production in response to a subsequent challenge by l-isoproterenol (desensitization). This loss in responsiveness is paralleled by a 20-30...

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Autors principals: Mallorga, P, Tallman, J F, Henneberry, R C, Hirata, F, Strittmatter, W T, Axelrod, J
Format: Artigo
Idioma:Inglês
Publicat: 1980
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Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC348490/
https://ncbi.nlm.nih.gov/pubmed/6246490
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