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Estimating Genetic Effects and Quantifying Missing Heritability Explained by Identified Rare-Variant Associations
Next-generation sequencing has led to many complex-trait rare-variant (RV) association studies. Although single-variant association analysis can be performed, it is grossly underpowered. Therefore, researchers have developed many RV association tests that aggregate multiple variant sites across a ge...
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| Main Authors: | , |
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| Format: | Artigo |
| Language: | Inglês |
| Published: |
Elsevier
2012
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3484659/ https://ncbi.nlm.nih.gov/pubmed/23022102 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ajhg.2012.08.008 |
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