Chronic overexpression of PNPLA3(I148M) in mouse liver causes hepatic steatosis

A genetic variant in PNPLA3 (PNPLA3(I148M)), a triacylglycerol (TAG) hydrolase, is a major risk factor for nonalcoholic fatty liver disease (NAFLD); however, the mechanism underlying this association is not known. To develop an animal model of PNPLA3-induced fatty liver disease, we generated transge...

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Bibliografiske detaljer
Main Authors: Li, John Zhong, Huang, Yongcheng, Karaman, Ruchan, Ivanova, Pavlina T., Brown, H. Alex, Roddy, Thomas, Castro-Perez, Jose, Cohen, Jonathan C., Hobbs, Helen H.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Clinical Investigation 2012
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3484461/
https://ncbi.nlm.nih.gov/pubmed/23023705
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI65179
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