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A Structure Based Model for the Prediction of Phospholipidosis Induction Potential of Small Molecules
Drug-induced phospholipidosis (PLD), characterized by an intracellular accumulation of phospholipids and formation of concentric lamellar bodies, has raised concerns in the drug discovery community, due to its potential adverse effects. To evaluate the PLD induction potential, 4,161 non-redundant dr...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3484221/ https://ncbi.nlm.nih.gov/pubmed/22725677 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ci3001875 |
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