DSIR: Assessing the Design of Highly Potent siRNA by Testing a Set of Cancer-Relevant Target Genes

Chemically synthesized small interfering RNA (siRNA) is a widespread molecular tool used to knock down genes in mammalian cells. However, designing potent siRNA remains challenging. Among tools predicting siRNA efficacy, very few have been validated on endogenous targets in realistic experimental co...

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Bibliographic Details
Main Authors: Filhol, Odile, Ciais, Delphine, Lajaunie, Christian, Charbonnier, Peggy, Foveau, Nicolas, Vert, Jean-Philippe, Vandenbrouck, Yves
Format: Artigo
Language:Inglês
Published: Public Library of Science 2012
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3484153/
https://ncbi.nlm.nih.gov/pubmed/23118925
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0048057
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