Optimization of Pellets Containing Solid Dispersion Prepared by Extrusion/Spheronization Using Central Composite Design and Desirability Function

Furosemide is a class IV biopharmaceutical classification system drug having poor water solubility and low bioavailability due to the hepatic first-pass metabolism and has a short half-life of 2 h. To overcome the above drawback, this study was carried to prepare and evaluate the pellets containing...

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Bibliographic Details
Main Authors: Singh, Gurinder, Pai, Roopa S., Devi, V. Kusum
Format: Artigo
Language:Inglês
Published: Medknow Publications & Media Pvt Ltd 2012
Subjects:
Pharmaceutics
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3483524/
https://ncbi.nlm.nih.gov/pubmed/23112533
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4103/0975-1483.100020
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