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Optimization of Pellets Containing Solid Dispersion Prepared by Extrusion/Spheronization Using Central Composite Design and Desirability Function
Furosemide is a class IV biopharmaceutical classification system drug having poor water solubility and low bioavailability due to the hepatic first-pass metabolism and has a short half-life of 2 h. To overcome the above drawback, this study was carried to prepare and evaluate the pellets containing...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Medknow Publications & Media Pvt Ltd
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3483524/ https://ncbi.nlm.nih.gov/pubmed/23112533 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4103/0975-1483.100020 |
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