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Lack of GPR88 enhances medium spiny neuron activity and alters motor- and cue-dependent behaviors
The striatum regulates motor control, reward, and learning. Abnormal function of striatal GABAergic medium spiny neurons (MSNs) is believed to contribute to the deficits in these processes that are observed in many neuropsychiatric diseases. The orphan G-protein-coupled receptor (GPCR) GPR88 is robu...
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| Hauptverfasser: | , , , , , , , , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2012
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3483418/ https://ncbi.nlm.nih.gov/pubmed/23064379 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nn.3239 |
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