Lack of GPR88 enhances medium spiny neuron activity and alters motor- and cue-dependent behaviors

The striatum regulates motor control, reward, and learning. Abnormal function of striatal GABAergic medium spiny neurons (MSNs) is believed to contribute to the deficits in these processes that are observed in many neuropsychiatric diseases. The orphan G-protein-coupled receptor (GPCR) GPR88 is robu...

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Hauptverfasser: Quintana, Albert, Sanz, Elisenda, Wang, Wengang, Storey, Granville P., Güler, Ali D., Wanat, Matthew J., Roller, Bryan A., La Torre, Anna, Amieux, Paul S., McKnight, G. Stanley, Bamford, Nigel S., Palmiter, Richard D.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2012
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3483418/
https://ncbi.nlm.nih.gov/pubmed/23064379
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nn.3239
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