Inhibition of the TWEAK/Fn14 pathway attenuates renal disease in nephrotoxic serum nephritis

Previously it was shown that the TNF superfamily member TWEAK (TNFSF12) acts through its receptor, Fn14, to promote proinflammatory responses in kidney cells, including the production of MCP-1, RANTES, IP-10 and KC. In addition, the TWEAK/Fn14 pathway promotes mesangial cell proliferation, vascular...

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Main Authors: Xia, Yumin, Campbell, Sean R., Broder, Anna, Herlitz, Leal, Abadi, Maria, Wu, Ping, Michaelson, Jennifer S., Burkly, Linda C., Putterman, Chaim
Format: Artigo
Sprog:Inglês
Udgivet: 2012
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3483377/
https://ncbi.nlm.nih.gov/pubmed/22982296
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.clim.2012.08.008
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