Quantitative Comparison of the Efficacy of Various Compounds in Lowering Intracellular Cholesterol Levels in Niemann-Pick Type C Fibroblasts

Niemann-Pick Type C disease (NPC) is a lethal, autosomal recessive disorder caused by mutations in the NPC1 and NPC2 cholesterol transport proteins. NPC’s hallmark symptoms include an accumulation of unesterified cholesterol and other lipids in the late endosomal and lysosomal cellular compartments,...

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Détails bibliographiques
Auteurs principaux: Wehrmann, Zachary T., Hulett, Tyler W., Huegel, Kara L., Vaughan, Kevin T., Wiest, Olaf, Helquist, Paul, Goodson, Holly
Format: Artigo
Langue:Inglês
Publié: Public Library of Science 2012
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3483179/
https://ncbi.nlm.nih.gov/pubmed/23144769
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0048561
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