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Lubiprostone targets prostanoid signaling and promotes ion transporter trafficking, mucus exocytosis and contractility

BACKGROUND AND AIM: Lubiprostone is a chloride channel activator in clinical use for the treatment of chronic constipation, but the mechanisms of action of the drug are poorly understood. The aim of this study was to determine whether lubiprostone exerts secretory effects in the intestine by membran...

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Detalhes bibliográficos
Main Authors: Jakab, Robert L., Collaco, Anne M., Ameen, Nadia A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3482986/
https://ncbi.nlm.nih.gov/pubmed/22923315
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s10620-012-2352-8
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