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Lubiprostone targets prostanoid signaling and promotes ion transporter trafficking, mucus exocytosis and contractility
BACKGROUND AND AIM: Lubiprostone is a chloride channel activator in clinical use for the treatment of chronic constipation, but the mechanisms of action of the drug are poorly understood. The aim of this study was to determine whether lubiprostone exerts secretory effects in the intestine by membran...
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| Auteurs principaux: | , , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
2012
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3482986/ https://ncbi.nlm.nih.gov/pubmed/22923315 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s10620-012-2352-8 |
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