Epidermal growth factor and expression of specific genes: effects on cultured rat pituitary cells are dissociable from the mitogenic response.

Cultured rat pituitary tumor cells, GH3/D6, which synthesize both growth hormone and prolactin, have cell-surface epidermal growth factor (EGF) receptor sites (34,000 per cell) that bind 125I-labeled EGF with a high affinity (Kd approximately 1 nM). Prolonged treatment of the cells with EGF did not...

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Autors principals: Johnson, L K, Baxter, J D, Vlodavsky, I, Gospodarowicz, D
Format: Artigo
Idioma:Inglês
Publicat: 1980
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC348277/
https://ncbi.nlm.nih.gov/pubmed/6244557
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