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Epidermal growth factor and expression of specific genes: effects on cultured rat pituitary cells are dissociable from the mitogenic response.

Cultured rat pituitary tumor cells, GH3/D6, which synthesize both growth hormone and prolactin, have cell-surface epidermal growth factor (EGF) receptor sites (34,000 per cell) that bind 125I-labeled EGF with a high affinity (Kd approximately 1 nM). Prolonged treatment of the cells with EGF did not...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Johnson, L K, Baxter, J D, Vlodavsky, I, Gospodarowicz, D
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 1980
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC348277/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/6244557/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.77.1.394
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