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Role of the degradation process in the mitogenic effect of epidermal growth factor

The protease inhibitor leupeptin inhibits the degradation process of (125)I-labeled epidermal growth factor ((125)I-EGF) by cultured bovine granulosa cells. At 80 μg/ml, leupeptin inhibited the appearance of degradation products of (125)I-EGF in the medium by 95% during 1 hr of incubation and by 90%...

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Bibliographische Detailangaben
Veröffentlicht in:Proc Natl Acad Sci U S A
Hauptverfasser: Savion, Naphtali, Vlodavsky, Israel, Gospodarowicz, Denis
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 1980
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC348516/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/6966398/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.77.3.1466
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