Deficiency of the Calcium-Sensing Receptor in the Kidney Causes Parathyroid Hormone–Independent Hypocalciuria

Rare loss-of-function mutations in the calcium-sensing receptor (Casr) gene lead to decreased urinary calcium excretion in the context of parathyroid hormone (PTH)–dependent hypercalcemia, but the role of Casr in the kidney is unknown. Using animals expressing Cre recombinase driven by the Six2 prom...

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Autors principals: Toka, Hakan R., Al-Romaih, Khaldoun, Koshy, Jacob M., DiBartolo, Salvatore, Kos, Claudine H., Quinn, Stephen J., Curhan, Gary C., Mount, David B., Brown, Edward M., Pollak, Martin R.
Format: Artigo
Idioma:Inglês
Publicat: American Society of Nephrology 2012
Matèries:
Basic Research
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3482734/
https://ncbi.nlm.nih.gov/pubmed/22997254
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1681/ASN.2012030323
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