Deficiency of the Calcium-Sensing Receptor in the Kidney Causes Parathyroid Hormone–Independent Hypocalciuria

Rare loss-of-function mutations in the calcium-sensing receptor (Casr) gene lead to decreased urinary calcium excretion in the context of parathyroid hormone (PTH)–dependent hypercalcemia, but the role of Casr in the kidney is unknown. Using animals expressing Cre recombinase driven by the Six2 prom...

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Detalhes bibliográficos
Main Authors: Toka, Hakan R., Al-Romaih, Khaldoun, Koshy, Jacob M., DiBartolo, Salvatore, Kos, Claudine H., Quinn, Stephen J., Curhan, Gary C., Mount, David B., Brown, Edward M., Pollak, Martin R.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Nephrology 2012
Assuntos:
Basic Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3482734/
https://ncbi.nlm.nih.gov/pubmed/22997254
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1681/ASN.2012030323
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