Deficiency of the Calcium-Sensing Receptor in the Kidney Causes Parathyroid Hormone–Independent Hypocalciuria

Rare loss-of-function mutations in the calcium-sensing receptor (Casr) gene lead to decreased urinary calcium excretion in the context of parathyroid hormone (PTH)–dependent hypercalcemia, but the role of Casr in the kidney is unknown. Using animals expressing Cre recombinase driven by the Six2 prom...

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Главные авторы: Toka, Hakan R., Al-Romaih, Khaldoun, Koshy, Jacob M., DiBartolo, Salvatore, Kos, Claudine H., Quinn, Stephen J., Curhan, Gary C., Mount, David B., Brown, Edward M., Pollak, Martin R.
Формат: Artigo
Язык:Inglês
Опубликовано: American Society of Nephrology 2012
Предметы:
Basic Research
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3482734/
https://ncbi.nlm.nih.gov/pubmed/22997254
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1681/ASN.2012030323
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