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Failure of Amino Acid Homeostasis Causes Cell Death following Proteasome Inhibition
The ubiquitin-proteasome system targets many cellular proteins for degradation and thereby controls most cellular processes. Although it is well established that proteasome inhibition is lethal, the underlying mechanism is unknown. Here, we show that proteasome inhibition results in a lethal amino a...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Cell Press
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3482661/ https://ncbi.nlm.nih.gov/pubmed/22959274 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2012.08.003 |
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