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A Bioinformatics Method Identifies Prominent Off-targeted Transcripts in RNAi Screens
Because off-target effects hamper interpretation and validation of RNAi screens, we developed a bioinformatics method, Genome-wide Enrichment of Seed Sequence matches (GESS), to identify candidate off-targeted transcripts from direct analysis of primary screening data. GESS identified a prominent of...
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| Main Authors: | , , , , , , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
2012
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3482495/ https://ncbi.nlm.nih.gov/pubmed/22343343 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nmeth.1898 |
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