Загрузка...

Low Molecular Weight Amidoximes that Act as Potent Inhibitors of Lysine-Specific Demethylase 1

The recently discovered enzyme lysine-specific demethylase 1 (LSD1) plays an important role in the epigenetic control of gene expression, and aberrant gene silencing secondary to LSD1 dysregulation is thought to contribute to the development of cancer. We reported that (bis)guanidines, (bis)biguanid...

Полное описание

Сохранить в:
Библиографические подробности
Главные авторы: Hazeldine, Stuart, Pachaiyappan, Boobalan, Steinbergs, Nora, Nowotarski, Shannon, Hanson, Allison S., Casero, Robert A., Woster, Patrick M.
Формат: Artigo
Язык:Inglês
Опубликовано: 2012
Предметы:
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3482425/
https://ncbi.nlm.nih.gov/pubmed/22876979
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm3002845
Метки: Добавить метку
Нет меток, Требуется 1-ая метка записи!