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Low Molecular Weight Amidoximes that Act as Potent Inhibitors of Lysine-Specific Demethylase 1

The recently discovered enzyme lysine-specific demethylase 1 (LSD1) plays an important role in the epigenetic control of gene expression, and aberrant gene silencing secondary to LSD1 dysregulation is thought to contribute to the development of cancer. We reported that (bis)guanidines, (bis)biguanid...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Hazeldine, Stuart, Pachaiyappan, Boobalan, Steinbergs, Nora, Nowotarski, Shannon, Hanson, Allison S., Casero, Robert A., Woster, Patrick M.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2012
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC3482425/
https://ncbi.nlm.nih.gov/pubmed/22876979
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm3002845
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