Mice Lacking the β4 Subunit of the Nicotinic Acetylcholine Receptor Show Memory Deficits, Altered Anxiety- and Depression-Like Behavior, and Diminished Nicotine-Induced Analgesia

RATIONALE: The role of β4-containing nicotinic acetylcholine receptors (nAChRs) in cognition, anxiety, depression, and analgesia in the absence of nicotine is unclear. METHODS: Wild-type (β4(+/+)) and knockout (β4(−/−)) mice for the nAChR β4 subunit were tested in behavioral tests assessing cognitiv...

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Detalles Bibliográficos
Main Authors: Semenova, Svetlana, Contet, Candice, Roberts, Amanda J., Markou, Athina
Formato: Artigo
Idioma:Inglês
Publicado: Oxford University Press 2012
Assuntos:
Original Investigation
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3482014/
https://ncbi.nlm.nih.gov/pubmed/22573727
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/ntr/nts107
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