Leptin upregulates caveolin-1 expression: Implications for development of atherosclerosis

OBJECTIVE: To determine the role of hyperleptinemia on caveolin-1 expression and leptin signaling. METHOD: Endothelial cells are critical to atherosclerosis development; therefore we investigated hyperleptinemia in cultured vascular endothelial cells. Dose-dependent effect of leptin on caveolin-1 ex...

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Bibliographic Details
Main Authors: Singh, Prachi, Peterson, Timothy E., Sert-Kuniyoshi, Fatima H., Jensen, Michael D., Somers, Virend K.
Format: Artigo
Language:Inglês
Published: 2010
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3482003/
https://ncbi.nlm.nih.gov/pubmed/21074769
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.atherosclerosis.2010.10.012
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