Leptin upregulates the expression of plasminogen activator inhibitor-1 in human vascular endothelial cells

A prothrombotic state in obesity may be partially responsible for the higher incidence of atherosclerotic complications. However the factors responsible for this prothrombotic state, linked with high levels of plasminogen activator inhibitor-1 (PAI-1), are not fully known. Leptin is elevated in obes...

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Bibliographic Details
Main Authors: Singh, Prachi, Peterson, Timothy E., Barber, Kara R., Kuniyoshi, Fatima Sert, Jensen, Andrus, Hoffmann, Michal, Shamsuzzaman, Abu S.M., Somers, Virend K.
Format: Artigo
Language:Inglês
Published: 2010
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2831408/
https://ncbi.nlm.nih.gov/pubmed/20051227
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbrc.2009.12.158
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