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A leukocyte-mimetic MRI contrast agent homes rapidly to activated endothelium and tracks with atherosclerotic lesion macrophage content
OBJECTIVE: Endothelial cell activation is an important mediator of monocyte recruitment to sites of vascular inflammation. We hypothesised that high-affinity dual-ligand microparticles of iron oxide, targeted to P-selectin and vascular cell adhesion molecule-1 (VCAM-1) (PV-MPIO), would identify acti...
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| Autors principals: | , , , , , , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
2012
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3481782/ https://ncbi.nlm.nih.gov/pubmed/22499989 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/ATVBAHA.111.241844 |
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