A leukocyte-mimetic MRI contrast agent homes rapidly to activated endothelium and tracks with atherosclerotic lesion macrophage content

OBJECTIVE: Endothelial cell activation is an important mediator of monocyte recruitment to sites of vascular inflammation. We hypothesised that high-affinity dual-ligand microparticles of iron oxide, targeted to P-selectin and vascular cell adhesion molecule-1 (VCAM-1) (PV-MPIO), would identify acti...

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Main Authors: McAteer, Martina A., Mankia, Kulveer, Ruparelia, Neil, Jefferson, Andrew, Nugent, Hannah B., Stork, Lee-Anne, Channon, Keith M., Schneider, Jurgen E., Choudhury, Robin P.
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3481782/
https://ncbi.nlm.nih.gov/pubmed/22499989
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/ATVBAHA.111.241844
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