Structure of the Bone Morphogenetic Protein Receptor ALK2 and Implications for Fibrodysplasia Ossificans Progressiva

Bone morphogenetic protein (BMP) receptor kinases are tightly regulated to control development and tissue homeostasis. Mutant receptor kinase domains escape regulation leading to severely degenerative diseases and represent an important therapeutic target. Fibrodysplasia ossificans progressiva (FOP)...

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Bibliografiske detaljer
Main Authors: Chaikuad, Apirat, Alfano, Ivan, Kerr, Georgina, Sanvitale, Caroline E., Boergermann, Jan H., Triffitt, James T., von Delft, Frank, Knapp, Stefan, Knaus, Petra, Bullock, Alex N.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2012
Fag:
Protein Structure and Folding
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3481300/
https://ncbi.nlm.nih.gov/pubmed/22977237
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.365932
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