Conformational Transitions Underlying Pore Opening and Desensitization in Membrane-embedded Gloeobacter violaceus Ligand-gated Ion Channel (GLIC)

Direct structural insight into the mechanisms underlying activation and desensitization remain unavailable for the pentameric ligand-gated channel family. Here, we report the structural rearrangements underlying gating transitions in membrane-embedded GLIC, a prokaryotic homologue, using site-direct...

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Main Authors: Velisetty, Phanindra, Chalamalasetti, Sreevatsa V., Chakrapani, Sudha
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2012
Assuntos:
Molecular Biophysics
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3481289/
https://ncbi.nlm.nih.gov/pubmed/22977232
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.401067
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