A Small-molecule Screen Yields Idiotype-specific Blockers of Neuromyelitis Optica Immunoglobulin G Binding to Aquaporin-4

Neuromyelitis optica (NMO) is an inflammatory demyelinating disease of the central nervous system caused by binding of anti-aquaporin-4 (AQP4) autoantibodies (NMO-IgG) to AQP4 on astrocytes. A screen was developed to identify inhibitors of NMO-IgG-dependent, complement-dependent cytotoxicity. Screen...

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Bibliographische Detailangaben
Hauptverfasser: Phuan, Puay-Wah, Anderson, Marc O., Tradtrantip, Lukmanee, Zhang, Hua, Tan, Joseph, Lam, Chiwah, Bennett, Jeffrey L., Verkman, A. S.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2012
Schlagworte:
Molecular Bases of Disease
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3481286/
https://ncbi.nlm.nih.gov/pubmed/22989877
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.408716
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