ANTI-AQUAPORIN-4 MONOCLONAL ANTIBODY BLOCKER THERAPY FOR NEUROMYELITIS OPTICA

OBJECTIVE: Neuromyelitis optica (NMO) is an inflammatory demyelinating disease of the central nervous system. Circulating autoantibodies (NMO-IgG) against astrocyte water channel aquaporin-4 (AQP4) cause complement- and cell-mediated astrocyte damage with consequent neuroinflammation and demyelinati...

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Main Authors: Tradtrantip, Lukmanee, Zhang, Hua, Saadoun, Samira, Phuan, Puay-Wah, Lam, Chiwah, Papadopoulos, Marios C., Bennett, Jeffrey L., Verkman, A.S.
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3314396/
https://ncbi.nlm.nih.gov/pubmed/22271321
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/ana.22657
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