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Failure of Prion Protein Oxidative Folding Guides the Formation of Toxic Transmembrane Forms
The mechanism by which pathogenic mutations in the globular domain of the cellular prion protein (PrP(C)) increase the likelihood of misfolding and predispose to diseases is not yet known. Differences in the evidences provided by structural and metabolic studies of these mutants suggest that in vivo...
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| 主要な著者: | , , , , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
American Society for Biochemistry and Molecular Biology
2012
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3481273/ https://ncbi.nlm.nih.gov/pubmed/22955286 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.398776 |
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