Targeted Gene Correction of Laminopathy-Associated LMNA Mutations in Patient-Specific iPSCs

Combination of stem cell-based approaches with gene-editing technologies represents an attractive strategy for studying human disease and developing therapies. However, gene-editing methodologies described to date for human cells suffer from technical limitations including limited target gene size,...

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Main Authors: Liu, Guang-Hui, Suzuki, Keiichiro, Qu, Jing, Sancho-Martinez, Ignacio, Yi, Fei, Li, Mo, Kumar, Sachin, Nivet, Emmanuel, Kim, Jessica, Soligalla, Rupa Devi, Dubova, Ilir, Goebl, April, Plongthongkum, Nongluk, Fung, Ho-Lim, Zhang, Kun, Loring, Jeanne F., Laurent, Louise C., Belmonte, Juan Carlos Izpisua
Format: Artigo
Sprog:Inglês
Udgivet: 2011
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3480729/
https://ncbi.nlm.nih.gov/pubmed/21596650
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stem.2011.04.019
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