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PARP-1 Modulation of mTOR Signaling in Response to a DNA Alkylating Agent
Poly(ADP-ribose) polymerase-1 (PARP-1) is widely involved in cell death responses. Depending on the degree of injury and on cell type, PARP activation may lead to autophagy, apoptosis or necrosis. In HEK293 cells exposed to the alkylating agent N-methyl-N’-nitro-N’-nitrosoguanine (MNNG), we show tha...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Public Library of Science
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3480502/ https://ncbi.nlm.nih.gov/pubmed/23110147 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0047978 |
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