Potential anti-aging agents suppress the level of constitutive mTOR- and DNA damage- signaling

Two different mechanisms are considered to be the primary cause of aging. Cumulative DNA damage caused by reactive oxygen species (ROS), the by-products of oxidative phosphorylation, is one of these mechanisms (ROS concept). Constitutive stimulation of mitogen- and nutrient-sensing mTOR/S6 signaling...

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Bibliografiske detaljer
Main Authors: Halicka, H. Dorota, Zhao, Hong, Li, Jiangwei, Lee, Yong-Syu, Hsieh, Tze-Chen, Wu, Joseph M., Darzynkiewicz, Zbigniew
Format: Artigo
Sprog:Inglês
Udgivet: Impact Journals LLC 2012
Fag:
Research Paper
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3615161/
https://ncbi.nlm.nih.gov/pubmed/23363784
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