Isolation of Reovirus T3D Mutants Capable of Infecting Human Tumor Cells Independent of Junction Adhesion Molecule-A

Mammalian Reovirus is a double-stranded RNA virus with a distinctive preference to replicate in and lyse transformed cells. On that account, Reovirus type 3 Dearing (T3D) is clinically evaluated as oncolytic agent. The therapeutic efficacy of this approach depends in part on the accessibility of the...

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Autors principals: van den Wollenberg, Diana J. M., Dautzenberg, Iris J. C., van den Hengel, Sanne K., Cramer, Steve J., de Groot, Raoul J., Hoeben, Rob C.
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2012
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3480499/
https://ncbi.nlm.nih.gov/pubmed/23110175
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0048064
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