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Carnitine Deficiency in OCTN2(−/−) Newborn Mice Leads to a Severe Gut and Immune Phenotype with Widespread Atrophy, Apoptosis and a Pro-Inflammatory Response

We have investigated the gross, microscopic and molecular effects of carnitine deficiency in the neonatal gut using a mouse model with a loss-of-function mutation in the OCTN2 (SLC22A5) carnitine transporter. The tissue carnitine content of neonatal homozygous (OCTN2(−/−)) mouse small intestine was...

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Bibliografiske detaljer
Main Authors: Sonne, Srinivas, Shekhawat, Prem S., Matern, Dietrich, Ganapathy, Vadivel, Ignatowicz, Leszek
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2012
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3480427/
https://ncbi.nlm.nih.gov/pubmed/23112839
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0047729
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