Calcium-activated chloride channel TMEM16A modulates mucin secretion and airway smooth muscle contraction

Mucous cell hyperplasia and airway smooth muscle (ASM) hyperresponsiveness are hallmark features of inflammatory airway diseases, including asthma. Here, we show that the recently identified calcium-activated chloride channel (CaCC) TMEM16A is expressed in the adult airway surface epithelium and ASM...

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Detalhes bibliográficos
Main Authors: Huang, Fen, Zhang, Hongkang, Wu, Meng, Yang, Huanghe, Kudo, Makoto, Peters, Christian J., Woodruff, Prescott G., Solberg, Owen D., Donne, Matthew L., Huang, Xiaozhu, Sheppard, Dean, Fahy, John V., Wolters, Paul J., Hogan, Brigid L. M., Finkbeiner, Walter E., Li, Min, Jan, Yuh-Nung, Jan, Lily Yeh, Rock, Jason R.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2012
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3479591/
https://ncbi.nlm.nih.gov/pubmed/22988107
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1214596109
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